Research Area: Migraine
9 ingredients studied for effects on Migraine — sorted by research relevance.
5-HTP (5-Hydroxytryptophan)
5-HTP is a serotonin precursor crossing the blood-brain barrier. Used for sleep and mood. Critical: avoid with SSRIs or MAO inhibitors due to serotonin syndrome risk.
Caffeine
The world's most widely consumed psychoactive substance. Hundreds of RCTs confirm effects on alertness, reaction time, endurance, and short-term cognition.
Vitamin B2 (Riboflavin)
Vitamin B2 is essential for energy metabolism and antioxidant defence. Most relevant for deficiency correction and potentially for migraine prevention in susceptible individuals.
Resveratrol
Known for sirtuin activation in animal models. Poor oral bioavailability (<1% free form) translates poorly to humans; a 2026 umbrella review found no convincing metabolic effects even in diabetics.
Magnesium
Magnesium is involved in over 300 enzymatic reactions. Low intake is common. The form significantly affects bioavailability and tolerability.
Vitamin A
Essential for vision, skin, and immune function. Clearly useful for deficiency, but high doses are toxic—especially in pregnancy.
Curcumin (Turmeric Extract)
Curcumin modulates inflammatory and oxidative pathways; moderate effects on CRP, IL-6, and joint pain—but only with enhanced formulations. Bioavailability is the limiting factor.
Myo-Inositol
Myo-inositol has solid RCT evidence for PCOS and insulin resistance. Promising but limited data for anxiety and panic disorder.
L-Tyrosin
L-Tyrosin is an amino acid precursor of dopamine, noradrenaline, and adrenaline. Studies show cognitive benefits under acute stress and sleep deprivation.