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Product Review

Life Extension Optimized Resveratrol

Life Extension · Capsule · 100 mg

Price/day

€0.50

Dose

100 mg

Servings/pack

60

Pack price

€29.95

Transparency Index

6.0/10

Acceptable A reasonable formulation for resveratrol enthusiasts. Human evidence remains weak — expectations should be tempered.

Rating breakdown

Evidence for ingredient 3.0/10

Resveratrol shows impressive lab results but has underperformed in large human RCTs. Clinical benefit in healthy individuals remains unclear.

Value for money 6.0/10

€0.50 per day for 100 mg trans-resveratrol plus companion compounds. Acceptable, but hard to justify given uncertain evidence.

Product quality 7.0/10

Life Extension sensibly combines resveratrol with related polyphenols. The trans-form (bioactive) is correctly declared.

Label honesty 7.0/10

Life Extension communicates cautiously and cites research. Some marketing text is more ambitious than the evidence supports.

Third-party testing 5.0/10

No external certification. Life Extension has a good industry reputation and tests internally, but no independent verification.

Product Description

Life Extension is one of the oldest US supplement brands, founded in 1980. Optimized Resveratrol combines 100 mg trans-resveratrol with quercetin and fisetin — two related polyphenols with similar proposed mechanisms.

What We Like

  • Trans-form: Only the trans-configuration is biologically active — correctly declared
  • Polyphenol combination: Quercetin and fisetin complement resveratrol mechanistically
  • Established brand: Life Extension is considered a reputable manufacturer

What We’re Missing

  • Human studies: Evidence does not support a clear recommendation for resveratrol in healthy individuals
  • Bioavailability: Liposomal resveratrol or pterostilbene (a resveratrol analog) may offer better absorption

Ingredient dossier

Known for sirtuin activation in animal models. Poor oral bioavailability (<1% free form) translates poorly to humans; a 2026 umbrella review found no convincing metabolic effects even in diabetics.

Read full dossier: Resveratrol →