Life Extension SAMe 400 mg

Life Extension · Tablet · 400 mg

Price/day

€1.47

Dose

400 mg

Servings/pack

Pack price

€44.00

Transparency Index

7.7/10

Recommended One of the most reliable SAMe picks for therapeutic dosing.

Rating breakdown

Evidence for ingredient 7.0/10

SAMe has solid data for mood and liver markers, particularly at 400–1600 mg.

Value for money 6.0/10

€1.47 per 400 mg is typical for pharmaceutical-grade quality, but not a bargain.

Product quality 9.0/10

Enteric-coated tablets, blister packaging, and the disulfate tosylate salt form optimally stabilize the active compound.

Label honesty 8.0/10

Labeling and instructions regarding dosing and interactions (e.g., SSRIs) are exemplary.

Third-party testing 7.0/10

Life Extension publishes COAs and tests every batch for potency.

Product Description

Life Extension delivers 400 mg SAMe disulfate tosylate per tablet. Blister packaging protects against moisture; enteric coating ensures release in the small intestine rather than the stomach.

What We Like

Disulfate tosylate form for maximum stability
Blister-packed — each tablet individually protected
cGMP manufacturing
400 mg dose aligned with clinical protocols

What We’re Missing

Premium price point
Only 30 servings — typically lasts one month
No vegan label (tablets may contain animal-derived excipients)

Usage Recommendation

1 tablet in the morning on an empty stomach with water. For therapeutic use, consult a physician; the dose may be split to 2 tablets daily (morning and midday). Do not combine with SSRIs without professional guidance.

Other SAMe products

NOW Foods SAMe 200 mg

7.4/10

Recommended

Ingredient dossier

SAMe supports mood, liver function, and methylation as a central methyl donor. It has clinical evidence but is regarded as more therapeutic than typical supplements.

Read full dossier: SAMe →