MikroScore

Research Area: Bone Health

16 ingredients studied for effects on Bone Health — sorted by research relevance.

Weak Evidence

Lactobacillus reuteri

Strain-specific probiotic with RCT evidence for bone health in older women. Reduced bone loss by ~50% over 12 months.

Likely safe
Strong Evidence

Calcium

Essential mineral for bones, muscles, and nerves. Meta-analyses show moderate bone effects in deficiency; high-dose supplements carry cardiovascular risks.

Likely safe EFSA ✓
Strong Evidence

Vitamin C (Ascorbic Acid)

Vitamin C is essential for collagen synthesis and other normal body functions, with approved EFSA claims. Megadoses show no clear benefit beyond adequate intake.

Likely safe EFSA ✓
Moderate Evidence

Vitamin K2 (MK-7)

Vitamin K2 activates calcium-regulating proteins and is studied primarily for bone and vascular health. MK-7 from natto demonstrates good bioavailability.

Likely safe EFSA ✓
Moderate Evidence

Taurin

Taurine is an amino acid with a central role in energy metabolism. Animal and observational data have sparked aging research interest; robust human evidence is far more limited.

Likely safe
Strong Evidence

Vitamin D3 + K2

Low vitamin D levels are common in northern climates. Supplementation is comparatively well studied in deficiency; K2 is often combined but has weaker standalone evidence.

Safe EFSA ✓
Strong Evidence

Iron

Essential for oxygen transport, energy metabolism, and immune function. Clearly effective when deficiency is confirmed — do not supplement without a lab diagnosis.

Caution EFSA ✓
Weak Evidence

Bor

Boron is discussed for bone, hormone, and inflammation support. Mechanistically interesting, but human evidence remains sparse.

Caution
Weak Evidence

Silicium

Silicon is marketed for skin, hair, nails and connective tissue. Biologically plausible but clinical evidence is limited.

Likely safe
Strong Evidence

Magnesium

Magnesium is involved in over 300 enzymatic reactions. Low intake is common. The form significantly affects bioavailability and tolerability.

Safe EFSA ✓
Moderate Evidence

Kollagen

Collagen is one of the most popular supplements. Human trials support benefits for skin elasticity and joint markers; broader anti-aging claims remain unproven.

Safe
Strong Evidence

Vitamin D3

Vitamin D3 is well supported for bone, muscle, and immune function when deficiency is confirmed. Without deficiency, additional benefit is significantly weaker — not a universal upgrade.

Likely safe EFSA ✓
Strong Evidence

Phosphor

Phosphorus is essential for bones, ATP and cell membranes. Deficiency is rare, and supplements are unnecessary for most people.

Likely safe EFSA ✓
Strong Evidence

Mangan

Manganese is an essential trace element for enzyme function, bone metabolism and antioxidant systems. Deficiency is rare; supplementation in healthy adults lacks clear evidence of benefit.

Caution EFSA ✓
Moderate Evidence

Vitamin K1

Vitamin K1 is essential for blood clotting and likely important for bone metabolism. Supplementation makes sense with low intake but is medically relevant for anticoagulant users.

Caution EFSA ✓
Strong Evidence

Vitamin A

Essential for vision, skin, and immune function. Clearly useful for deficiency, but high doses are toxic—especially in pregnancy.

Caution EFSA ✓