Research Area: Liver Health
26 ingredients studied for effects on Liver Health — sorted by research relevance.
Ergothionein
Ergothioneine is a sulfur-containing amino acid found primarily in mushrooms, studied for potential antioxidant and age-related benefits despite limited human evidence.
Quercetin
Quercetin is a plant flavonoid with antioxidant and senolytic potential. Human senolytic evidence is limited to tiny pilot studies using Dasatinib+Quercetin combined — not quercetin alone.
NAC (N-Acetylcysteine)
NAC is a glutathione precursor with established medical use. As a longevity supplement (especially as GlyNAC), early human data is promising but limited.
Folsäure (Vitamin B9)
Essential B-vitamin for DNA synthesis, cell division, and homocysteine metabolism. Strong evidence for neural tube defect prevention in pregnancy. L-methylfolate benefits MTHFR carriers.
Vitamin K2 (MK-7)
Vitamin K2 activates calcium-regulating proteins and is studied primarily for bone and vascular health. MK-7 from natto demonstrates good bioavailability.
TMG (Trimethylglycin)
TMG provides methyl groups and correlates with lower homocysteine. Biochemically plausible but as a healthy aging supplement, it's more niche than essential.
Vitamin D3 + K2
Low vitamin D levels are common in northern climates. Supplementation is comparatively well studied in deficiency; K2 is often combined but has weaker standalone evidence.
Apigenin
Apigenin is a flavonoid from chamomile and parsley that inhibits CD38, an enzyme that degrades NAD+. Complements NMN/NR approaches. Early human evidence.
Ashwagandha (Withania somnifera)
Ashwagandha is an Ayurvedic adaptogen backed by multiple RCTs for stress and cortisol reduction. Sleep and testosterone effects are promising but come from small studies.
EGCG (Grüntee-Extrakt)
EGCG is green tea's most abundant catechin, studied for metabolism and cellular protection. High-dose supplements carry documented liver toxicity risks.
Vitamin B12 (Cobalamin)
Vitamin B12 is essential for nerve function, DNA synthesis, and homocysteine metabolism. Deficiency is common in vegans, older adults, and metformin users and causes irreversible nerve damage.
Schisandra
Classic adaptogenic berry used for stress resilience and liver support. Traditional use is extensive, but human clinical evidence remains modest and inconsistent.
L-Citrullin
L-citrulline may boost nitric oxide production and is linked in studies to improved blood flow and endurance performance during physical exertion.
SAMe
SAMe supports mood, liver function, and methylation as a central methyl donor. It has clinical evidence but is regarded as more therapeutic than typical supplements.
Silymarin (Mariendistel)
Silymarin is the classic liver compound. Evidence exists but is considerably mixed compared to its reputation in detox and liver support products.
Iron
Essential for oxygen transport, energy metabolism, and immune function. Clearly effective when deficiency is confirmed — do not supplement without a lab diagnosis.
Vitamin B3 (Niacin)
Vitamin B3 is essential and a NAD+ precursor. While deficiency correction matters, high-dose niacin causes side effects—benefits for aging in healthy adults remain unclear.
Sulforaphan
Sulforaphan activates Nrf2-dependent defence mechanisms and is typically sourced from broccoli sprouts. Strong preclinical evidence; clinical data still building.
Resveratrol
Known for sirtuin activation in animal models. Poor oral bioavailability (<1% free form) translates poorly to humans; a 2026 umbrella review found no convincing metabolic effects even in diabetics.
Vitamin D3
Vitamin D3 is well supported for bone, muscle, and immune function when deficiency is confirmed. Without deficiency, additional benefit is significantly weaker — not a universal upgrade.
Glutathion
Glutathione is the body's most celebrated antioxidant. As a supplement, the evidence is far less impressive than its reputation.
Betain (Trimethylglycin)
Betaine is a natural methyl donor that lowers homocysteine and shows modest strength gains in some studies, but evidence is inconsistent and limited.
Vitamin A
Essential for vision, skin, and immune function. Clearly useful for deficiency, but high doses are toxic—especially in pregnancy.
Curcumin (Turmeric Extract)
Curcumin modulates inflammatory and oxidative pathways; moderate effects on CRP, IL-6, and joint pain—but only with enhanced formulations. Bioavailability is the limiting factor.
Cholin
Choline is essential for cell membranes, liver, and acetylcholine production. Important if underprovisioned—but not all choline forms deliver the same brain benefits.
Jod
Iodine is essential for thyroid hormones and cognitive development. Germany faces structural deficiency despite salt iodization. EFSA-approved claims.