Research Area: Neuroprotection
13 ingredients studied for effects on Neuroprotection — sorted by research relevance.
Spermidine
Natural polyamine from wheat germ and legumes. Robustly induces autophagy in cell and animal models; early human trials show positive signals for cognition and heart function.
Astaxanthin
Astaxanthin is a membrane-spanning carotenoid antioxidant. Small RCTs show consistent benefits for skin protection and visual fatigue; cardiovascular and longevity data remain limited.
NAC (N-Acetylcysteine)
NAC is a glutathione precursor with established medical use. As a longevity supplement (especially as GlyNAC), early human data is promising but limited.
Fisetin
Fisetin is a flavonoid senolytic that clears senescent ('zombie') cells in animal studies. Human trials are ongoing; robust clinical evidence is still lacking.
Vitamin B12 (Cobalamin)
Vitamin B12 is essential for nerve function, DNA synthesis, and homocysteine metabolism. Deficiency is common in vegans, older adults, and metformin users and causes irreversible nerve damage.
Phosphatidylserin
Phosphatidylserine is a membrane phospholipid with an EFSA-approved health claim for maintaining normal cognitive function at 100 mg/day.
Lion's Mane (Hericium erinaceus)
Edible mushroom with active compounds (hericenones, erinacines) that stimulate NGF and BDNF synthesis. Early RCTs in MCI and anxiety show positive signals — evidence remains preliminary.
Vitamin E (Tocopherole)
Vitamin E: 8 lipid-soluble antioxidants protecting cell membranes. Natural mixed tocopherols are generally safe; high-dose synthetic forms carry risks documented in the SELECT trial.
Alpha-Liponsäure (R-ALA)
Mitochondrial antioxidant with dual water/fat solubility. R-form significantly more bioavailable than racemic mixture. Evidence strongest for diabetic neuropathy.
Creatine (Creatine Monohydrate)
Creatine is one of the most thoroughly studied supplements for high-intensity muscular work. The strongest evidence is from strength and power sports; further applications are still being explored.
Glutathion
Glutathione is the body's most celebrated antioxidant. As a supplement, the evidence is far less impressive than its reputation.
Cholin
Choline is essential for cell membranes, liver, and acetylcholine production. Important if underprovisioned—but not all choline forms deliver the same brain benefits.
L-Tyrosin
L-Tyrosin is an amino acid precursor of dopamine, noradrenaline, and adrenaline. Studies show cognitive benefits under acute stress and sleep deprivation.