Research Area: Inflammation
26 ingredients studied for effects on Inflammation — sorted by research relevance.
Hesperidin
Citrus flavonoid with promising vascular and anti-inflammatory evidence in preclinical and small human studies, but overall support remains moderate.
GlyNAC (Glycin + NAC)
GlyNAC combines glycine and N-acetylcysteine (NAC) to support glutathione synthesis. Early clinical data in healthy aging contexts are promising but still limited.
Ergothionein
Ergothioneine is a sulfur-containing amino acid found primarily in mushrooms, studied for potential antioxidant and age-related benefits despite limited human evidence.
Quercetin
Quercetin is a plant flavonoid with antioxidant and senolytic potential. Human senolytic evidence is limited to tiny pilot studies using Dasatinib+Quercetin combined — not quercetin alone.
Astaxanthin
Astaxanthin is a membrane-spanning carotenoid antioxidant. Small RCTs show consistent benefits for skin protection and visual fatigue; cardiovascular and longevity data remain limited.
NAC (N-Acetylcysteine)
NAC is a glutathione precursor with established medical use. As a longevity supplement (especially as GlyNAC), early human data is promising but limited.
Omega-3 (EPA + DHA)
Omega-3 fatty acids (EPA + DHA) are among the most thoroughly studied supplements. Evidence is strong for triglycerides and high-risk cardiovascular patients; smaller for healthy individuals.
Taurin
Taurine is an amino acid with a central role in energy metabolism. Animal and observational data have sparked aging research interest; robust human evidence is far more limited.
Apigenin
Apigenin is a flavonoid from chamomile and parsley that inhibits CD38, an enzyme that degrades NAD+. Complements NMN/NR approaches. Early human evidence.
EGCG (Grüntee-Extrakt)
EGCG is green tea's most abundant catechin, studied for metabolism and cellular protection. High-dose supplements carry documented liver toxicity risks.
Baicalin
Baicalin is a TCM flavonoid with an interesting anti-inflammatory and neuroprotective story, but clinical evidence remains early-stage.
Lactobacillus reuteri
Strain-specific probiotic with RCT evidence for bone health in older women. Reduced bone loss by ~50% over 12 months.
Hydroxytyrosol
Hydroxytyrosol is an olive polyphenol studied for oxidative stress and vascular markers. One of the few EFSA-approved polyphenol claims.
Iron
Essential for oxygen transport, energy metabolism, and immune function. Clearly effective when deficiency is confirmed — do not supplement without a lab diagnosis.
Bor
Boron is discussed for bone, hormone, and inflammation support. Mechanistically interesting, but human evidence remains sparse.
Glycin
Glycine is the smallest amino acid, required for glutathione, collagen, and creatine. In GlyNAC form, it shows promise for aging markers in older adults.
Pterostilben
Pterostilbene is a resveratrol analogue from blueberries with superior bioavailability (~80% vs 20%). Similar mechanisms (SIRT1, AMPK) but fewer human studies to date.
Probiotics
Probiotics are live microorganisms with strain-specific effects. Strong evidence for antibiotic diarrhea and IBS; product quality varies dramatically.
Alpha-Liponsäure (R-ALA)
Mitochondrial antioxidant with dual water/fat solubility. R-form significantly more bioavailable than racemic mixture. Evidence strongest for diabetic neuropathy.
Sulforaphan
Sulforaphan activates Nrf2-dependent defence mechanisms and is typically sourced from broccoli sprouts. Strong preclinical evidence; clinical data still building.
Akkermansia muciniphila
Akkermansia muciniphila is a gut bacterium linked to better metabolism, intestinal barrier function, and healthy aging in observational studies.
Luteolin
Luteolin is an intriguing flavonoid with neuroprotective and anti-inflammatory potential. The catch: human evidence lags significantly behind the mechanistic story.
Rutin
Rutin is a flavonoid with vascular and antioxidant properties. Biologically plausible but clinically a niche topic with limited human evidence.
Curcumin (Turmeric Extract)
Curcumin modulates inflammatory and oxidative pathways; moderate effects on CRP, IL-6, and joint pain—but only with enhanced formulations. Bioavailability is the limiting factor.
Fucoidan
Fucoidan is a sulfated polysaccharide from brown seaweed with growing evidence for prebiotic gut effects, muscle health, and cardiovascular markers.
L-Glutamine
L-glutamine is the most abundant free amino acid in the body. Clinically well-supported in critical care; evidence for oral supplementation in healthy individuals is more limited.