Research Area: Oxidative Stress
38 ingredients studied for effects on Oxidative Stress — sorted by research relevance.
Spermidine
Natural polyamine from wheat germ and legumes. Robustly induces autophagy in cell and animal models; early human trials show positive signals for cognition and heart function.
GlyNAC (Glycin + NAC)
GlyNAC combines glycine and N-acetylcysteine (NAC) to support glutathione synthesis. Early clinical data in healthy aging contexts are promising but still limited.
Ergothionein
Ergothioneine is a sulfur-containing amino acid found primarily in mushrooms, studied for potential antioxidant and age-related benefits despite limited human evidence.
Quercetin
Quercetin is a plant flavonoid with antioxidant and senolytic potential. Human senolytic evidence is limited to tiny pilot studies using Dasatinib+Quercetin combined — not quercetin alone.
Calcium
Essential mineral for bones, muscles, and nerves. Meta-analyses show moderate bone effects in deficiency; high-dose supplements carry cardiovascular risks.
Astaxanthin
Astaxanthin is a membrane-spanning carotenoid antioxidant. Small RCTs show consistent benefits for skin protection and visual fatigue; cardiovascular and longevity data remain limited.
Molybdän
Molybdenum is an essential trace element for certain enzymes. Deficiency is rare, and there is usually little reason for supplementation.
NAC (N-Acetylcysteine)
NAC is a glutathione precursor with established medical use. As a longevity supplement (especially as GlyNAC), early human data is promising but limited.
Vitamin C (Ascorbic Acid)
Vitamin C is essential for collagen synthesis and other normal body functions, with approved EFSA claims. Megadoses show no clear benefit beyond adequate intake.
Vitamin K2 (MK-7)
Vitamin K2 activates calcium-regulating proteins and is studied primarily for bone and vascular health. MK-7 from natto demonstrates good bioavailability.
Taurin
Taurine is an amino acid with a central role in energy metabolism. Animal and observational data have sparked aging research interest; robust human evidence is far more limited.
Fisetin
Fisetin is a flavonoid senolytic that clears senescent ('zombie') cells in animal studies. Human trials are ongoing; robust clinical evidence is still lacking.
Ashwagandha (Withania somnifera)
Ashwagandha is an Ayurvedic adaptogen backed by multiple RCTs for stress and cortisol reduction. Sleep and testosterone effects are promising but come from small studies.
Beta-Alanin
Beta-alanine elevates muscle carnosine and improves high-intensity exercise performance in 60–240-second efforts; it's a sports tool, not a longevity supplement.
Hydroxytyrosol
Hydroxytyrosol is an olive polyphenol studied for oxidative stress and vascular markers. One of the few EFSA-approved polyphenol claims.
Iron
Essential for oxygen transport, energy metabolism, and immune function. Clearly effective when deficiency is confirmed — do not supplement without a lab diagnosis.
Vitamin E (Tocopherole)
Vitamin E: 8 lipid-soluble antioxidants protecting cell membranes. Natural mixed tocopherols are generally safe; high-dose synthetic forms carry risks documented in the SELECT trial.
Glycin
Glycine is the smallest amino acid, required for glutathione, collagen, and creatine. In GlyNAC form, it shows promise for aging markers in older adults.
Pterostilben
Pterostilbene is a resveratrol analogue from blueberries with superior bioavailability (~80% vs 20%). Similar mechanisms (SIRT1, AMPK) but fewer human studies to date.
Caffeine
The world's most widely consumed psychoactive substance. Hundreds of RCTs confirm effects on alertness, reaction time, endurance, and short-term cognition.
Zinc
Zinc is involved in hundreds of enzymes and is essential for immune function, DNA repair, and hormone synthesis. Low intake is not uncommon in older adults and vegans.
Alpha-Liponsäure (R-ALA)
Mitochondrial antioxidant with dual water/fat solubility. R-form significantly more bioavailable than racemic mixture. Evidence strongest for diabetic neuropathy.
Sulforaphan
Sulforaphan activates Nrf2-dependent defence mechanisms and is typically sourced from broccoli sprouts. Strong preclinical evidence; clinical data still building.
Vitamin B2 (Riboflavin)
Vitamin B2 is essential for energy metabolism and antioxidant defence. Most relevant for deficiency correction and potentially for migraine prevention in susceptible individuals.
PQQ
PQQ is often linked to mitochondria and cellular energy. It sounds elegant, but human evidence remains limited.
Resveratrol
Known for sirtuin activation in animal models. Poor oral bioavailability (<1% free form) translates poorly to humans; a 2026 umbrella review found no convincing metabolic effects even in diabetics.
Creatine (Creatine Monohydrate)
Creatine is one of the most thoroughly studied supplements for high-intensity muscular work. The strongest evidence is from strength and power sports; further applications are still being explored.
L-Theanine
L-theanine promotes relaxed alertness via alpha-wave activation. Best evidence for caffeine synergy; moderate effects on stress markers. Alone, cognitive benefits are limited.
Mangan
Manganese is an essential trace element for enzyme function, bone metabolism and antioxidant systems. Deficiency is rare; supplementation in healthy adults lacks clear evidence of benefit.
Glutathion
Glutathione is the body's most celebrated antioxidant. As a supplement, the evidence is far less impressive than its reputation.
Kupfer
Copper is essential for enzymes, iron metabolism, and connective tissue. Justified for deficiency—but high-dose supplementation isn't advisable for otherwise healthy individuals.
Selen
Selenium is essential for glutathione peroxidases and thyroid hormones. In Germany and Austria, selenium supply is structurally low due to selenium-depleted soils.
Melatonin
Melatonin regulates the sleep–wake cycle and has antioxidant properties. Evidence is strongest for jet lag and sleep onset; prescription-only above 0.5 mg/day in Germany.
Rhodiola Rosea (Rosenwurz)
Rhodiola rosea is an adaptogen with RCT evidence for mental fatigue and stress relief. Data are promising but show some heterogeneity across studies.
Rutin
Rutin is a flavonoid with vascular and antioxidant properties. Biologically plausible but clinically a niche topic with limited human evidence.
Lutein & Zeaxanthin
Xanthophyll carotenoids that concentrate in the macula. Strong evidence for slowing AMD progression (25% reduction in AREDS2). Also studied for contrast sensitivity, glare, and cognitive function.
Curcumin (Turmeric Extract)
Curcumin modulates inflammatory and oxidative pathways; moderate effects on CRP, IL-6, and joint pain—but only with enhanced formulations. Bioavailability is the limiting factor.
L-Tyrosin
L-Tyrosin is an amino acid precursor of dopamine, noradrenaline, and adrenaline. Studies show cognitive benefits under acute stress and sleep deprivation.